Postdoc myelin imaging
€ 3.546 - € 5.538 per maandTijdelijk
Royal Netherlands Academy of Arts and Sciences (KNAW)
What you will be doing
We are seeking a highly motivated postdoctoral researcher with strong technical expertise to study the oligodendrocyte myelin sheaths in brain tissue in health and disease. Many brain disorders, including rare genetic white matter disorders (leukodystrophies), but also more common diseases such as Multiple Sclerosis, are characterized by white matter pathology including myelin swelling (vacuolization), damage, loss or remodeling. Recently, we found that myelin swelling is not always the start of myelin loss, but that it can be followed by repair (Arafa et al. Science 391, eadr4661, 2026). Neuronal activity contributes to myelin swelling, but the mechanisms and dynamics underlying myelin swelling and repair are poorly understood. Leveraging advanced microscopy approaches you will investigate myelin in living tissue (Higgins, Al-Naqib et al. 10.64898/2026.05.15.725074) to determine the biophysical and molecular mechanisms associated with myelin remodeling. This project is a collaboration with Dr. Rogier Min of the Amsterdam Leukodystrophy Center (ALC), Amsterdam UMC. Well-validated mouse models for various leukodystrophies offer opportunities to study myelin swelling and remodeling in disease contexts, taking an important step towards a better understanding of this understudied, but common phenomenon and building bridges to the clinic.
You will be joining a highly collaborative neuroscience research environment and benefit from state-of-the-art infrastructure. The Kole group is renowned for their fundamental cellular neuron-glia studies of myelinated and axons. We have new high-end in vitro and in vivo electrophysiological infrastructure, optogenetic and high-speed one and two-photon imaging setups. Through close collaboration with Dr Min at the Amsterdam Leukodystrophy Center, you will have the opportunity to investigate myelin remodeling in clinically relevant disease models, adding a strong translational dimension to the project. This is a full-time position for 1.0 fte (38 h/week), initially for one year. Subject to satisfactory performance, the contract will be extended for an additional two years. You will have ample opportunities to further develop your scientific knowledge and technical skills through courses offered by the Academy, participation in (inter)national conferences, and additional opportunities for personal development. Terms of employment
Depending on education and experience the minimum salary is € 3.546 and the maximum salary is € 5.538 gross per month for a full-time appointment (scale 10 cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP. The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment). For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW . Applying for a Certificate of Good Conduct can be part of the employment procedure. Diversity & Inclusion
The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy. We will not respond to any supplier enquiries based on this job advertisement.
We are seeking a highly motivated postdoctoral researcher with strong technical expertise to study the oligodendrocyte myelin sheaths in brain tissue in health and disease. Many brain disorders, including rare genetic white matter disorders (leukodystrophies), but also more common diseases such as Multiple Sclerosis, are characterized by white matter pathology including myelin swelling (vacuolization), damage, loss or remodeling. Recently, we found that myelin swelling is not always the start of myelin loss, but that it can be followed by repair (Arafa et al. Science 391, eadr4661, 2026). Neuronal activity contributes to myelin swelling, but the mechanisms and dynamics underlying myelin swelling and repair are poorly understood. Leveraging advanced microscopy approaches you will investigate myelin in living tissue (Higgins, Al-Naqib et al. 10.64898/2026.05.15.725074) to determine the biophysical and molecular mechanisms associated with myelin remodeling. This project is a collaboration with Dr. Rogier Min of the Amsterdam Leukodystrophy Center (ALC), Amsterdam UMC. Well-validated mouse models for various leukodystrophies offer opportunities to study myelin swelling and remodeling in disease contexts, taking an important step towards a better understanding of this understudied, but common phenomenon and building bridges to the clinic.
Requirements
What you will be contributing- A PhD obtained within the past four years in neuroscience or a related research field.
- Demonstrated experience with single-cell electrophysiology and/or live functional imaging from neurons and/or glia (e.g. 2P/SCoRe).
- Experience (> 2 yrs) with brain-tissue preparation methods preferably involving mouse models.
- Demonstrated capacity to publish research findings in peer-reviewed journals.
- Highly proficient in spoken and written English.
- Experience supervising master/PhD students in research projects.
- Excellent teamwork and communication skills.
- Certification under Article 9 of the Dutch Experiments on Animals Act, or a comparable EU certification for experimental animal use, is an advantage.
- Proficiency with programming languages (Python, MATLAB, R) is a plus.
Contract terms
What do we offer?You will be joining a highly collaborative neuroscience research environment and benefit from state-of-the-art infrastructure. The Kole group is renowned for their fundamental cellular neuron-glia studies of myelinated and axons. We have new high-end in vitro and in vivo electrophysiological infrastructure, optogenetic and high-speed one and two-photon imaging setups. Through close collaboration with Dr Min at the Amsterdam Leukodystrophy Center, you will have the opportunity to investigate myelin remodeling in clinically relevant disease models, adding a strong translational dimension to the project. This is a full-time position for 1.0 fte (38 h/week), initially for one year. Subject to satisfactory performance, the contract will be extended for an additional two years. You will have ample opportunities to further develop your scientific knowledge and technical skills through courses offered by the Academy, participation in (inter)national conferences, and additional opportunities for personal development. Terms of employment
Depending on education and experience the minimum salary is € 3.546 and the maximum salary is € 5.538 gross per month for a full-time appointment (scale 10 cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP. The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment). For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW . Applying for a Certificate of Good Conduct can be part of the employment procedure. Diversity & Inclusion
The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy. We will not respond to any supplier enquiries based on this job advertisement.
Vacature geplaatst op 11 dagen geleden
Soortgelijke banen die u mogelijk interesserenOp basis van de vacature Postdoc myelin imaging in Amsterdam
€ 3.706 - € 5.760 per maand
...researcher with strong technical expertise to study the oligodendrocyte myelin sheaths in brain tissue in health and disease. Many brain... ...with single-cell electrophysiology and/or live functional imaging from neurons and/or glia (e.g. 2P/SCoRe); Experience ( 2 yrs...PostDoc€ 3.546 - € 5.538 per maand
...anyone who recognises themselves in the profile to apply, even if you do not meet all the requirements. Contract terms An exciting postdoc position in a socially-engaged organisation with a supportive project team and an active early-career scientist community. At VU...PostDocMet contractFulltime- ...skills. For both experiments and simulations, you will learn all the necessary methods & techniques in our group, and a PhD student or postdoc will be your daily supervisor. Working conditions At the start of the traineeship your trainee plan will be set out, in...PostDocStageTrainee
€ 3.546 - € 5.538 per maand
...UvA - University of Amsterdam Amsterdam, Netherlands € 3.546 - € 5.538 per month gross In this postdoc you will lead research on physics-informed (and physics-grounded) world models and agents: how to consolidate and transfer physical knowledge into learning...PostDoc€ 3.546 - € 5.538 per maand
UvA - University of Amsterdam Amsterdam, Netherlands € 3.546 - € 5.538 per month gross What you will do You will join a fast paced, tightly aligned team building, testing, and iterating cutting edge technology in a startup style environment. You will...PostDocStartup€ 4.725 - € 5.758 per maand
...and applies them to real-life applications such as wind-turbine wakes and CO2 transport. SYMBIOSIS consists of several PhD and postdoc positions (6 in total). Depending on the background of the candidate, the focus will be more on stochastic fundamentals, on...PostDocParttime- ...skills. For both experiments and simulations, you will learn all the necessary methods & techniques in our group, and a PhD student or postdoc will be your daily supervisor. Working conditions At the start of the traineeship your trainee plan will be set out, in...PostDocStageTraineeOp afstand werken
- ...home to 250 researchers, including over 60 PhD students and 30 postdocs. Research at Sanquin is organized in four strategic themes: Anemia... ...sorting, macromolecular mass spectrometry and proteomics, and imaging. Many of our scientists have academic affiliations with Dutch...PostDocFulltime
€ 3.630 - € 5.758 per maand
...femtosecond to attosecond time-scale semiconductor spectroscopy, imaging and metrology techniques in the soft-X-ray spectral range based... ...range of employment benefits . ARCNL assists any new foreign Postdoc with housing and visa applications and compensates their...PostDocMet contractFulltime€ 3.706 - € 4.925 per maand
...between frontline workers and citizens. The project involves academic and societal partners working together. We are looking for a postdoc that will carry out the work of a sub-project focusing on the micro-level environment in which conflict encounters occur, identifying...PostDocMet contractFulltime€ 3.546 - € 5.538 per maand
...research group and interacting with colleagues with diverse backgrounds? The Institute of Physics (IoP) is looking for ambitious postdocs. Your research is part of the Soft Matter Group: Join Us! We are seeking exceptional candidates for a postdoc in the Soft Matter...PostDocMet contract€ 4.492 - € 6.148 per maand
...relationship to users’ subjectively placed (dis)trust in the technology. To help addressing these questions, we are looking for a postdoc with several years of experience in doing interdisciplinary research at the intersection of information law, digital technologies,...PostDocFulltime- ...vivo targeting of hematopoietic stem cells. We are looking for a postdoc with experience in nanoparticle-mediated gene delivery as well... ...sorting, macromolecular mass spectrometry and proteomics, and imaging. Many of our scientists have academic affiliations with Dutch Universities...PostDocFulltime
€ 3.546 - € 5.538 per maand
We will be hiring a Postdoc on a project to investigate Nihilistic Violent Extremist (NVE) groups – that is, radical online groups (consisting of mostly adolescents and young adults) that are notorious for committing a broad range of crimes, consisting of members who appear...PostDocMet contractFulltime€ 3.546 - € 5.538 per maand
...that nobody else has seen? If yes, then you might want to join the Ultracold Strontium Group at t he Institute of Physics as a postdoc on our exciting journey towards superradiant and zero-deadtime clocks. Join Us! Optical clocks have reached a precision of better...PostDocMet contractStartup€ 3.546 - € 5.538 per maand
...physics that nobody else has seen? If yes, then you might want to join the Ultracold Strontium Group at the Institute of Physics as a postdoc on our Sr tweezer experiment. Join us! Join our strontium tweezer quantum simulation/computing team! We pioneer methods to...PostDocMet contractStartup€ 3.546 - € 5.538 per maand
...5538,00 gross per month, on a full-time basis. This is based on UFO (University Job Classification) profile for the position of a Postdoc. The exact salary depends on your education and experience. a position for 1 FTE. The initial contract will be for 1 year, which...PostDocMet contractParttimeFulltime€ 3.965 - € 5.050 per maand
...professionals. Wij bieden een postdoctorale opleiding die volledig door KPMG wordt gefinancierd als je deze kwalificatie nog niet hebt (postdoc RE-opleiding). Om je carrière de ondersteuning te bieden die je verwacht, krijg je een coach en een ontwikkelingsmanager om je te...PostDocFulltimeOpdracht€ 3.546 - € 5.538 per maand
...avoiding harm to others, and whether disruptions in ACC–mPFC circuits contribute to pathological aggression. The postdoc will use functional ultrasound imaging, behavioural assays, physiological recordings, computational modelling, and pathway-selective chemogenetic...PostDoc€ 4.374 - € 4.885 per maand
...(NSCR) heeft binnen het vijfjarige VIDI-project “ Immersed in Interventions ?” twee vacatures voor een gepromoveerde onderzoeker (postdoc) en een promovendus. Je bekijkt momenteel de vacature voor de postdoc-positie. De PhD-vacature is afzonderlijk gepubliceerd. Veel...PostDocMet contractFulltime€ 3.115 per maand
...Rechtshandhaving (NSCR) heeft binnen het VIDI-project “ Immersed in Interventions ?” twee vacatures voor een gepromoveerde onderzoeker (postdoc) en een promovendus. Je bekijkt momenteel de vacature voor de PhD-positie. De postdoc-vacature is afzonderlijk gepubliceerd....PostDocMet contractParttimeFulltime32 uur week€ 3.059 - € 3.881 per maand
...onderdeel uit van de onderzoeksgroep van het DeMoCraft-consortium. DemoCraft besteedt veel aandacht aan de ontwikkeling van promovendi en postdocs. Zo word je actief begeleid op het inter- en transdisciplinair samenwerken en netwerken buiten je eigen discipline en...PostDocMet contractFulltimeVoor 3 maanden- ...avoiding harm to others, and whether disruptions in ACC–mPFC circuits contribute to pathological aggression. The postdoc will use functional ultrasound imaging , behavioural assays, physiological recordings, computational modelling, and pathway-selective chemogenetic...PostDoc
€ 4.552 per maand
...we are exploring the possible applications of XUV radiation in imaging and metrology with a nanometer resolution, specifically in holography... ...of employment benefits . AMOLF assists any new foreign Postdoc with housing and visa applications and compensates their...PostDocFulltime€ 3.706 - € 5.760 per maand
...landscape? Do you enjoy solving both technical and societal challenges? The Intelligent Data Engineering lab (INDElab) is looking for a postdoc in the BridgeMD project. Join Us! We are looking for a postdoctoral researcher who can help us develop technology to help...PostDocMet contract€ 3.546 - € 5.538 per maand
...responsibilities: The list of tasks is not exhaustive and covers aspects of the project that may or may not be taken on by the Postdoc. If there are skills you already have or would like to develop, or a topic you are particularly interested in, please mention these...PostDocMet contractPloegendienst€ 3.546 - € 5.538 per maand
...section at the Amsterdam School of Economics (ASE). To get a good understanding of the nascent technology focal for the work, the postdoc will also engage with personnel at the Faculty of Science and with relevant industry partners in SUSGREEN (Sustainable Fuels from...PostDocFulltimeThuiswerk€ 3.059 - € 3.881 per maand
...Christmas and 1 January; ~ multiple courses to follow from our Teaching and Learning Centre; ~ a complete educational program for postdocs; ~ multiple courses on topics such as leadership for academic staff; ~ multiple courses on topics such as time management,...PostDocMet contractFulltime€ 3.546 - € 5.538 per maand
Our theory group is a worldwide leader in studying the statistical physics of living systems. We currently have an opening for an Vici funded 2.5-year Post Doc position. In this project, we seek to uncover the fundamental interaction rules that govern collective cell migration...PostDocMet contractFulltime€ 3.546 - € 5.538 per maand
...mechanisms underlying STM function across evolutionary distant lineages is lacking. This project aims to combine a multitude of -omics and imaging techniques as well as functional studies to work towards deep, large-scale analyses of STM evolution and action. The focus will lie...PostDocMet contractFulltime
Wilt u meer vacatures ontvangen?
Abonneer u om vacatures voor Postdoc myelin imaging te ontvangen. Solliciteer als eerste!
