Postdoctoral Researcher in Quantum Computing for Bioinformatics

ph3Join Us! /h3 pThe Biosystems Data Analysis (BDA) group at the University of Amsterdam is looking for a postdoctoral researcher to develop and rigorously benchmark quantum-computing approaches for high-impact problems in bioinformatics. /p pThis project is part of the Faculty of Science's new Quantum Simulation for Molecular and Material Design (Q-MMD) programme. You will join a growing interdisciplinary team at the cutting edge of quantum application; four Q-MMD seed projects across the Faculty of Science, together with a Lead Scientist Quantum Applications currently being recruited. This team will explore where quantum and hybrid quantum-classical methods can make a real scientific difference, build reusable expertise and create the basis for future academic and public-private collaborations. At BDA, you will be embedded in a group whose experience is in advanced methods for biological and biomedical data. /p pWe welcome applications from candidates with expertise in quantum computing who are motivated to cross disciplinary boundaries towards bioinformatics and computational biology. You do not need to arrive as an expert in both fields. /p h3This is what you will do /h3 pYou will develop quantum-algorithm prototypes within existing bioinformatics workflows and benchmark them transparently against state-of-the-art classical approaches. In consultation with the project leaders and collaborators, you will focus on one or both of two complementary directions: /p ul liprotein structure-based enzyme specificity and biocatalysis, including computationally demanding tasks such as pose search in high-dimensional binding landscapes, optimisation of catalytic-pocket conformations, sampling of ligand-binding modes, and improved scoring of enzyme-substrate interactions; /li liDNA sequence analysis, for example sequence alignment, assembly, distance computation, or phylogenetic inference, as applicable to microbiomes and human-microbiome interactions, such as outbreak-related strain reconstruction, or phasing and assembly of complex immune-system loci. /li /ul pYour tasks and responsibilities will include: /p ul lisurveying and selecting quantum or hybrid quantum-classical methods with credible potential for the chosen biological problems; /li lidesigning reproducible proof-of-concept studies, implementing prototypes and evaluating them on suitable simulated and/or real biological datasets; /li licomparing accuracy, scalability, resource requirements and scientific usefulness with strong classical baselines, and clearly identifying both opportunities and limitations; /li liworking closely with bioinformatics researchers, the incoming Lead Scientist Quantum Application, colleagues in the other Q-MMD seed projects as well as scientists in the wider quantum ecosystem at UvA; /li liwhere appropriate, connecting prototypes to available quantum-computing infrastructure and hardware partners, including through the wider Amsterdam quantum ecosystem; /li litaking a leading role in scientific publications, open and reusable research software, presentations and/or knowledge-transfer activities; /li lihelping formulate the project's valorisation strategy and develop follow-up proposals, including collaborative and public-private projects; /li licontributing to the supervision of Bachelor’s and Master’s students and to an inclusive, collaborative research culture. /li /ul h3What we ask of you /h3 pYou are a curious and rigorous researcher who enjoys learning across disciplines. You can translate an ambitious methodological idea into a testable computational study, communicate openly about negative as well as positive results, and work effectively with collaborators who use different scientific languages. /p pYou /p ul lihold a PhD in bioinformatics, computational biology, computer science, quantum information/quantum computing, computational chemistry, applied mathematics, physics, or a closely related field; /li lihave strong programming and computational research skills, and experience building reproducible analysis or simulation workflows; /li lihave demonstrable expertise in one of the following domains and the motivation to acquire working knowledge of the complementary domain: ul liquantum computation; /li libioinformatics or computational biology expertise in the project's core applications: biological sequence/structure analysis, molecular modelling, and/or optimisation and algorithms; /li /ul /li lihave a research record appropriate to your career stage and the ability to communicate results clearly in publications, presentations and collaborative meetings; /li licommunicate fluently in written and spoken English and work constructively in an interdisciplinary, international team. /li /ul pExperience with quantum software frameworks, high-performance computing, open-source software development, or collaboration with external partners is an advantage. We do not expect candidates to cover this entire list. /p h3This is what we offer you /h3 pWe offer a temporary employment contract for 38 hours per week for a period of 18 months, with a probationary period of three months in accordance with UvA policy. The preferred starting date is as soon as possible. /p pThe gross monthly salary, based on 38 hours per week and dependent on relevant experience, is €3.706 to €5.760. This does not include 8% holiday allowance and 8.3% year-end allowance. The UFO profile Researcher 4 is applicable. A favourable tax agreement, the "30% ruling", may apply to non-Dutch applicants. The Collective Labour Agreement of Universities of the Netherlands is applicable. /p pCurious about our extensive secondary benefits package? You can read more about it here. /p h3You will work in this team /h3 pYou will be appointed in the Biosystems Data Analysis group at the Swammerdam Institute for Life Sciences (SILS). The group develops and applies computational methods to understand biological systems, with research themes that include DNA sequence analysis, microbial communities and human-microbiome interactions, protein function, enzyme specificity and computational biocatalysis. /p pThe position is embedded in Q-MMD, the quantum-simulation programme of the Faculty's Molecular and Material Design Technology Hub. The programme connects four seed projects: quantum machine learning for molecular and material design; quantum computing for bioinformatics; quantum approaches for safe and sustainable molecular design; and benchmarking quantum simulations of materials against state-of-the-art numerical methods. Regular cross-project exchange will let you learn from different application domains while contributing bioinformatics challenges, benchmarks and software to a shared programme. /p pYou will collaborate with the incoming Lead Scientist Quantum Applications, whose role connects the MMD programme with QuSoft and the wider quantum ecosystem. QuSoft, founded by UvA and CWI, contributes expertise ranging from quantum information theory and algorithm design to quantum simulation and implementation. The wider network also includes partners such as SURF. This wider ecosystem makes the postdoc an opportunity to help shape an emerging field at a moment when questions, methods and standards for useful quantum applications are still being defined. /p pThe Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavour, food agricultural, and high-tech industries, and revolve around 4 main themes, Cell Systems biology, Neurosciences, Microbiology and Green Life Sciences. /p pThe Faculty of Science has a student body of around 8,000, as well as 1,800 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain. /p pWant to know more about our organisation? Read more about working at the University of Amsterdam. /p h3Contact /h3 pIf you have any questions or do you require additional information? Please contact: /p ul liProf. Dr. Aalt-Jan van DIjk, /li liProf. Dr. Kareljan Schoutens, /li liDr. Anna Heintz-Buschart, /li /ul pApplications should include the following information (all files besides your CV should be submitted in one single PDF file): /pul lia detailed CV including the months (not just years) when referring to your education and work experience; /li lia list of publications; /li lithe names and email addresses of two references who can provide letters of recommendation. /li /ul pA knowledge security check can be part of the selection procedure. (For details: national knowledge security guidelines) /p /p #J-18808-Ljbffr